ISIS MER NeuroExplorer: Combination of MER with MEPs for quantitative side effect determination in real time

ProductsFunctional NeurosurgeryISIS MERISIS MER NeuroExplorer
ISIS MER NeuroExplorerPrecision through synergy – Experience the future of intraoperative neurophysiology: Our innovative software combines MER, LFP and MEP technologies in an intelligent platform designed to take precision and safety to a new level.

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Software modules

Item no.: 504408ISIS Software MEPFor recording motor evoked potentials (MEP)

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Item no.: 504423ISIS Software Scalp-EEGFor recording an electroencephalogram (EEG) and local field potential (LFP) as a raw signal and spectral analysis (CSA/DSA) for software version 8

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Item no.: 504416ISIS Software MERFor recording microelectrode signals (MER)

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NeuroExplorer 8 Synergy – Flexibility redefined

NeuroExplorer 8.1 streamlines neurophysiological monitoring by recording motor evoked potentials (MEPs) and enabling quantitative side effect assessment through integrated MER-MEP analysis. The software automatically calculates RMS values and performs baseline normalisation.
Clinical workflow integration is enhanced through comprehensive reporting capabilities that capture screenshots, clinical comments, and anesthesia parameters in a single interface. Flexible data export supports multiple formats (XLSX, CSV, EDF) for seamless integration with existing clinical systems and research workflows.

Product features

Precision through synergy

The innovative combination of microelectrode recording (MER) and motor evoked potentials (MEPs) enables precise quantitative determination of side effects during DBS implantations. The synergistic use of both methods allows real-time monitoring of both neural activity in the target area and the functional effects on surrounding motor pathways. This dual strategy provides additional targeting guidance and enables surgeons to detect even the smallest changes in neurophysiological parameters before they manifest as clinically relevant side effects.

Quantitative side effect determination by combining MER with motor evoked potentials (MEPs)

Safety through analysis

Comprehensive online analysis tools ensure high patient safety through continuous real-time evaluation of neurophysiological signals. Automatic spike rate analysis and normalised root mean square calculation (nRMS) of MER signals provide quantitative measures for neural activity, while spectral analysis of local field potentials (LFP) provides deeper insights into local network dynamics. Automatic peak detection of MEPs supports immediate assessment of motor integrity. This multi-layered analysis strategy reduces dependence on subjective signal interpretation and provides the medical team with objective, data-based decision-making criteria for improving the effects of the permanent electrode.

Online analysis options MER (spike rate and nRMS), LFP (spectral power density map), MEP (peak detection) to support signal interpretation

Trust through overview

The user-friendly visualisation of MER signals creates trust through complete transparency and traceability of the surgical procedure. Intuitive timeline navigation enables users to switch effortlessly between current and historical measurement data to identify trends and retrospectively analyse critical decision-making moments. This chronological presentation not only supports intraoperative decision-making, but also serves as valuable documentation for postoperative evaluation and quality assurance. The clear, concise presentation of complex neurophysiological data reduces the cognitive load on the surgical team and promotes a safe, efficient way of working.

Intuitive display of MER signals with timeline for easy access to historical data

Efficiency through simplicity

The completely redesigned user interface combines modern design principles with the specific requirements of neurosurgical workflows. By consistently reducing the design to the essentials and intelligently arranging the operating elements, efficiency in the operating theatre is to be significantly increased. The intuitive menu navigation and contextual information display reduce the training time for new users, while experienced users benefit from improved workflows and shorter navigation times. This sophisticated balance between functional completeness and user-friendliness contributes significantly to stress reduction during complex neurosurgical procedures.

New and modern user interface

Flexibility for research

The integrated online streaming interface opens up new dimensions for neurosurgical research and individual data analysis. Real-time transmission of all measurement data allows seamless connection of external analysis systems, machine learning algorithms or specialised research applications. This openness of the system enables research institutions and hospitals to implement their own evaluation algorithms, develop innovative analysis methods or collect data for retrospective studies. Standardised data transfer ensures compatibility with common analysis platforms and promotes interdisciplinary collaboration between hospitals and research.

Online data streaming interface enables data transfer and individual evaluation in real time